Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent

J Med Chem. 1992 Aug 7;35(16):3081-4. doi: 10.1021/jm00094a025.

Authors

J D Bloom¹, M D Dutia, B D Johnson, A Wissner, M G Burns, E E Largis, J A Dolan, T H Claus

Affiliation

¹ Medical Research Division, Lederle Laboratories, American Cyanamid Company, Pearl River, New York 10965.

PMID: 1354264
DOI: 10.1021/jm00094a025

No abstract available

MeSH terms

Adipose Tissue / metabolism
Adrenergic beta-Agonists / metabolism
Adrenergic beta-Agonists / pharmacology*
Animals
Diabetes Mellitus, Type 2 / drug therapy
Hypoglycemic Agents / pharmacology*
Lipolysis / drug effects
Male
Mice
Mice, Obese
Obesity / drug therapy*
Substrate Specificity

Substances

Adrenergic beta-Agonists
Hypoglycemic Agents